Phase 2 Results

SideOut-BCA-002 / 50 patients / Completed

Results of the second phase of the Side-Out Protocol (Side-Out II) were presented at the San Antonio Breast Cancer Symposium (SABCS), an annual meeting attracting professionals and patients from all over the globe. The mission of SABCS is “to provide state-of-the-art information on breast cancer research” and to serve as a “forum for interaction, communication, and education for a broad spectrum of researchers, health professionals, and those with a special interest in breast cancer”.

Mariaelena Pierobon, MD, MPH, presented the results on behalf of the Side-Out Protocol research team. In simple terms, researchers concluded that the proteins expressed by the various tumors were dependent on the location of the metastasis (the spread of cancer from one part of the body to another), suggesting that the most effective drugs for a particular patient could be decided based on where his/her breast cancer spread. This also revealed that tumors that have metastasized to a certain part of the body share a distinct signature.

Poster Presentations

2013 AACR Annual Meeting

2014 San Antonio Breast Cancer Symposium

  • Pathway activation mapping of metastatic breast cancer identifies potential organ-specific signatures: implications for patient stratification to targeted treatment.

2015 San Antonio Breast Cancer Symposium

  • The AKT-mTOR pathway as a potential organ-specific drug target signature of hepatic metastases from breast cancer.

2016 American Society of Clinical Oncology Annual Meeting

2016 San Antonio Breast Cancer Symposium

2018 AACR Annual meeting

For more details about the trial or to learn about how to become a participant, contact Bryant Dunetz at [email protected] or 703-615-8740